High Uric Acid, Causes and Symptoms

high uric acid

Although we have heard about the problem of high uric acid in the blood for a long time, our understanding of this problem is not complete. For years, uric acid has been thought to be out.

But this belief is wrong because the uric acid has been identified as a sign of a number of health complications such as metabolic abnormalities, circulatory problems.

The increase in uric acid in the blood leads to many problems including arthritis, gout, kidney stones formation, kidney problems. So it is necessary to maintain healthy eating habits is the appropriate medication to reduce the levels of uric acid in the blood.

You may need to limit the intake of foods rich in purine – meat, poultry, seafood, and legumes. First, we need to understand the causes of high uric acid in the blood.


What is the high uric acid in the blood?


The total is responsible for producing 70% of uric acid daily and is filtered to 30%. In cases where the kidney fails to keep pace with the daily secretion, the body system increases its load to the intestine to compensate for the decrease in total production.

Thus, uric acid is the definitive product of the metabolism of purine in humans. It is a soluble element and is analyzed in a more difficult way.

About 1/3 uric acid is produced internally while the remaining one-third is obtained through dietary urea. Compared to animals, humans have low levels of uric acid, due to a lack of mineral enzymes and a relatively lower rate of uric acid secretion.

The rise of uric acid in the blood is a health condition called hyperuricemia. Uric acid passes through the liver and enters the bloodstream. Most of the secretions get rid of the body through the urine or pass through the intestine to obtain normal levels of uric acid.

Normal uric acid levels reach 6,024 mg / dl (females), 7.0-23 mg / dl (for males). Normal values may vary from laboratory to laboratory. The test of uric acid in the blood measures the amount of uric acid in the blood sample.


It is important to realize that uric acid levels in the blood are purine. Purines are compounds that contain nitrogen and produced internally within the body or come from outside the body of purine-containing foods. purine acid breaks down in uric acid.

When uric acid levels increase, extra purine may accumulate in the special tissues to form the crystals and this causes the rise of uric acid in the blood.

When you experience problems of uric acid level rise in the blood can cause the formation of solid crystals formed inside the joints and this painful condition accumulates in the joints and adjacent tissues form solid bone deposits and also cause the formation of kidney stones.

It is reported that one out of every five people has a high uric acid level and may be associated with gout or kidney stone formation but most people who suffer from uric acid rise have no symptoms or related problems.


Causes of high uric acid.


Medical reasons.


There are a range of medical problems that cause uric acid to rise. Because uric acid is eliminated through the urine and when it accumulates it can be due to kidney failure or deficiency and impaired kidney function:

Total insufficiency.

One of the most common causes of uric acid elevation is kidney failure. In the case of renal failure, uric acid is retained in the blood because the kidney is unable to function properly to secrete other organic compounds that compete to get rid of it.

Problems with metabolism.

Other health complications such as high blood pressure, obesity, insulin resistance are all metabolic problems that contribute to the reduction of urinary secretions in the kidney.


Diuretic drugs, low-dose salicylates, cycosporin, nicotinic acid, which were associated with impaired overall performance.

Genetics problems.

This may be a rare case, especially patients suffering from the experience of kidney failure gradually resulting in low rate of uric acid secretion.


Hypertension and associated drugs cause hyperuricemia in the blood.


There are health problems that lead to high acidity in the blood such as diabetic ketoacidosis, white acidosis, all these cases result in impaired kidney function.


Often, pre-eclampsia is associated with high levels of uric acid and therefore causes hyperuricemia in the blood.

Exposure to lead.

Clinical studies have shown that occupational exposure or prolonged exposure to lead can affect kidney function.


Nutritional reasons.


There are many external factors may cause Hyperuricemia such as a diet containing high purine or internal factors.

Diet .

When you eat a diet rich in purine, a component found in a large number of meat and organic foods and legumes that contribute to the excess of uric acid.

Increase DNA turnover.

Of the results of this syndrome is uric acid, the patients who suffer from this syndrome are more likely to develop gout and kidney stones.

Fructose found in foods and beverages.

Fructose increases uric content in the blood by increasing metabolism. In addition, studies have shown that fructose plays a role in reducing kidney function and excretion of uric acid.

Rapid decrease in weight.

The enhanced breakdown of tissues resulting from unhealthy or rapid weight loss may result in more uric acid and decrease its secretion due to sudden and rapid change in uric levels.


Signs of uric acid rise in blood.


Common symptoms.

Common symptoms common to uric acid in the blood include pain, inflammation, swelling, redness, fever, chills, chronic fatigue. These symptoms usually start suddenly at night.

Joints affected.

According to the specialists, the rise of high uric acid affects the extra joints. Which include ankles, knees, heels and fingers. With the first attack of high uric acid attack on other joints.

 Duration of common symptoms.

The severe pain in the joint reaches its peak within 12 – 24 hours of onset of symptoms. According to the Mayo Clinic website, once the pain is most severe and discomfort in the joint reaches from several days to a few weeks. Repeated attacks result in permanent damage to the joints.

Skin Symptoms.

After a long period of uric acid rise in the body, uric acid crystals begin to form subcutaneous masses. These lumps are illegal and usually occur in the toes, hands and elbows.

Symptoms of kidney problems.

When uric acid crystals settle in the urinary tract, they cause kidney stones. They are more common in men than women, resulting in back pain, stomach, hip, nausea, vomiting and bloody urine


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